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DOSING & ADMINISTRATION

DEXILANT CAN BE TAKEN WITH OR WITHOUT FOOD

Unlike lansoprazole and esomeprazole, which should be taken before eating, DEXILANT can be taken without regard to food.

DOSING INFORMATION

Indication Recommended dose Frequency
Healing of EE 60 mg Once daily for up to 8 weeks
Maintenance of healed EE 30 mg Once daily*
Symptomatic non-erosive GERD 30 mg Once daily for 4 weeks.
*Controlled studies did not extend beyond 6 months.
  • DEXILANT should be swallowed whole. Alternatively, capsules can be opened, sprinkled on 1 tablespoon of applesauce, and swallowed immediately. Granules should not be chewed. Do not store for later use.
  • While DEXILANT can be taken without regard to food, some patients may benefit from administering the dose prior to a meal if post-meal symptoms do not resolve under post-fed conditions
  • DEXILANT 30 mg should be considered for patients with moderate hepatic impairment

Reference: 1. DEXILANT (dexlansoprazole) package insert, Takeda Pharmaceuticals America, Inc.

DEXILANT is indicated for:

  • Healing all grades of erosive esophagitis (EE) for up to 8 weeks
  • Maintaining healing of EE and relief of heartburn for up to 6 months
  • Treating heartburn associated with symptomatic non-erosive gastroesophageal reflux disease (GERD) for 4 weeks

Important Safety Information

  • DEXILANT is contraindicated in patients with known hypersensitivity to any component of the formulation. Hypersensitivity and anaphylaxis have been reported with DEXILANT use.
  • Symptomatic response with DEXILANT does not preclude the presence of gastric malignancy.
  • Long-term and multiple daily dose PPI therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist, or spine. Patients should use the lowest dose and shortest duration of PPI therapy appropriate to the condition being treated.
  • Hypomagnesemia has been reported rarely with prolonged treatment with PPIs.
  • Most commonly reported adverse reactions were diarrhea (4.8%), abdominal pain (4.0%), nausea (2.9%), upper respiratory tract infection (1.9%), vomiting (1.6%), and flatulence (1.6%).
  • Do not co-administer atazanavir with DEXILANT because atazanavir systemic concentrations may be substantially decreased. DEXILANT may interfere with absorption of drugs for which gastric pH is important for bioavailability (e.g., ampicillin esters, digoxin, iron salts, ketoconazole). Patients taking concomitant warfarin may require monitoring for increases in international normalized ratio (INR) and prothrombin time. Increases in INR and prothrombin time may lead to abnormal bleeding and even death. Concomitant tacrolimus use may increase tacrolimus whole blood concentrations.

Please see the full Prescribing Information for DEXILANT.

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